Intraoperative Hypotension in Pancreatoduodenectomy: A Randomized Trial of General Versus Combined Anesthesia
Recruiting now · Not applicable
Conditions studied: Pancreatic Neoplasms, Hypotension, Pancreatoduodenectomy
In brief
This randomized clinical trial compares the hemodynamic effects of general anesthesia versus combined general anesthesia (thoracic epidural) in patients undergoing pancreatoduodenectomy. The primary aim is to assess the incidence of intraoperative hypotension and related adverse events. Secondary outcomes includes vasopressor requirements, transfusion needs, postoperative complications, intensive care unit admission, hospital length of stay, and mortality.
Key facts
- Study ID
- NCT06953193
- Run by
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
- People needed
- 206
- Starts
- 2025-04-07
- Expected to finish
- 2030-04-30
- Last updated by the study team
- 2026-04-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Signed written informed consent.
- Patients scheduled for elective pancreatoduodenectomy at National Institute of Medical Sciences and Nutrition Salvador Zubirán.
- No contraindications for neuroaxial anesthesia (epidural catheter placement), including:
- Generalized or localized infection at the puncture site.
- Thrombocytopenia.
- Coagulation disorders.
- Intracranial hypertension.
- Patient refusal.
You may not qualify if…
- Age under 18 years.
- Pregnancy.
- Inability to randomize the case due to specific circumstances (such as contraindications to epidural use), resulting in non-eligibility based on participation criteria.
Where it is running
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán — Mexico City, Mexico City, Mexico (enrolling)
Full record on ClinicalTrials.gov
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