Investigating Periprosthetic Fracture Cultures in Arthroplasty

Recruiting now

Conditions studied: Periprosthetic Fracture Around Prosthetic Joint Implant

In brief

This study aims to improve how doctors diagnose infections in patients with broken bones around joint replacements. Currently, there are no clear guidelines to help determine when an infection is present, making treatment decisions difficult. By studying how often infections are found through lab tests and identifying factors that predict infection, the investigators hope to create better ways to diagnose and care for these patients.

Key facts

Study ID

NCT06952738

Run by

University of Chicago

People needed

200

Starts

2025-10-01

Expected to finish

2027-10-31

Last updated by the study team

2025-12-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (>18 years old) with periprosthetic fractures around primary or revision hip or knee arthroplasty
• Patients requiring operative management for these fractures (fixation or revision arthroplasty)
• Patients presenting to the University of Chicago Medical Center during two (2) year period (October 2025 to October 2027)

You may not qualify if…

• Patients undergoing non-operative management for periprosthetic fractures
• Any documented or reported history of past prosthetic joint infection of the involved joint
• Sinus tract at the time of presentation at the involved joint

Where it is running

• The University of Chicago Medical Center — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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