A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
Recruiting now · Phase 3
Conditions studied: Endometrial Cancer
In brief
Researchers are looking for new ways to treat people with proficient mismatch repair (pMMR) endometrial cancer (EC) that is advanced or recurrent. * EC is a type of cancer that starts in the tissues inside the uterus (womb) * pMMR indicates that certain normal proteins are present in the cancer cells * Advanced means the cancer has spread locally or to other parts of the body (metastatic) and cannot be removed with surgery * Recurrent means the cancer came back after surgery Sacituzumab tirumotecan (also known as sac-TMT) and pembrolizumab are the study medicines. Sac-TMT is an antibody drug conjugate (ADC). An ADC attaches to specific targets on cancer cells and delivers treatment to destroy those cells. The goal of this study is to learn if people who receive sac-TMT with pembrolizumab live longer and without the cancer getting worse compared to people who receive pembrolizumab alone.
Key facts
- Study ID
- NCT06952504
- Run by
- Merck Sharp & Dohme LLC
- People needed
- 1123
- Starts
- 2025-05-22
- Expected to finish
- 2032-05-24
- Last updated by the study team
- 2026-08-05
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
Where it is running
- Alaska Women's Cancer Care ( Site 6036) — Anchorage, Alaska, United States (enrolling)
- CHAO Family Comprehensive Cancer Center and Ambulatory Care ( Site 5014) — Irvine, California, United States (enrolling)
- University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 6020) — Orange, California, United States (enrolling)
- John Muir Health Cancer Center ( Site 6028) — Walnut Creek, California, United States (enrolling)
- Yale University School of Medicine ( Site 6009) — New Haven, Connecticut, United States (enrolling)
- MedStar Washington Hospital Center ( Site 5005) — Washington D.C., District of Columbia, United States (enrolling)
- Florida Cancer Specialists - South ( Site 7003) — Fort Myers, Florida, United States (enrolling)
- UF Health Davis Cancer Pavilion and Shands Med Plaza ( Site 6026) — Gainesville, Florida, United States (enrolling)
- Mount Sinai Braman Comprehensive Cancer Center ( Site 6031) — Miami Beach, Florida, United States (enrolling)
- AdventHealth Orlando-AdventHealth Medical Group Gynecological Oncology ( Site 6002) — Orlando, Florida, United States (enrolling)
- Florida Cancer Specialists ( Site 7002) — St. Petersburg, Florida, United States (enrolling)
- Florida Cancer Specialists East ( Site 7001) — West Palm Beach, Florida, United States (enrolling)
- St. Joseph's/Candler Health System ( Site 6021) — Savannah, Georgia, United States (enrolling)
- University of Chicago Medical Center ( Site 5002) — Chicago, Illinois, United States (enrolling)
- Parkview Research Center ( Site 6008) — Fort Wayne, Indiana, United States (enrolling)
- Women's Cancer Care ( Site 6010) — Covington, Louisiana, United States (enrolling)
- TRIALS 365 ( Site 6005) — Shreveport, Louisiana, United States (enrolling)
- Maine Medical Center - Scarborough Campus ( Site 6042) — Scarborough, Maine, United States (enrolling)
- Tufts Medical Center ( Site 6052) — Boston, Massachusetts, United States (enrolling)
- Minnesota Oncology Hematology, PA ( Site 8003) — Minneapolis, Minnesota, United States (enrolling)
- St. Dominic's Hospital ( Site 5004) — Jackson, Mississippi, United States (enrolling)
- Holy Name Medical Center ( Site 6011) — Teaneck, New Jersey, United States (enrolling)
- University of New Mexico Comprehensive Cancer Center ( Site 6046) — Albuquerque, New Mexico, United States (enrolling)
- Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 6055) — Mineola, New York, United States (enrolling)
- University of South Alabama, Mitchell Cancer Institute ( Site 6033) — Mobile, Alabama, United States (enrolling)
Full record on ClinicalTrials.gov
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