The Impact of Daily Intake of Short-chain Fatty Acids on Cardiometabolic Risk Factors in Individuals at Risk for Metabolic Syndrome
Recruiting now · Not applicable
Conditions studied: Energy Expenditure, Metabolic Syndrome, Anthropometry, Body Composition, Glycemia, Lipaemia, Metabolomics, Blood Pressure
In brief
During this study, the effect of short-chain fatty acids on blood lipaedemia, glycemia, anthropometrics, blood pressure and energy expenditure will be investigated.
Key facts
- Study ID
- NCT06951386
- Run by
- KU Leuven
- People needed
- 50
- Starts
- 2025-02-11
- Expected to finish
- 2026-02-28
- Last updated by the study team
- 2025-05-04
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- male and female participants
- central obesity ( BMI ≥ 25 kg/m² or waist circumference ≥ 80 cm for women/ ≥ 94 cm for men)
- One additional risk factor for metabolic syndrome:
- Insulin resistance (HOMA-IR ≥ 1.7 or fasting glucose ≥ 100 mg/dl)
- Triglyceride concentration ≥ 150 mg/dl
- HDL-cholesterol < 40 mg/dl for women/ < 50 mg/dl for men
- Systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg
- knowledge of English
You may not qualify if…
- gastrointestinal disorders such as IBD, IBS, celiac disease, chronic constipation, chronic diarrhoea
- history of abdominal surgery, except for appendectomy
- Use of antihypertensive, cholesterol lowering, glucose-regulating drugs and corticosteroids
- Use of antibiotics 3 months prior to the start or during the study
- Use of probiotics and prebiotics 2 weeks prior to the start of the study/ during the study
- Being on weight loss, gluten-free, lactose-free or vegan diet
- Pregnancy, lactation or wish to become pregnant
- Previous or current substance/ alcohol dependence or abuse
- Hyper- or hypothyroidism
- Allergy or intolerance to oat milk
Where it is running
- KU Leuven/ UZ Leuven — Leuven, Vlaams-Brabant, Belgium (enrolling)
Full record on ClinicalTrials.gov
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