Pupillometry in Delayed Sleep Wake Phase Disorder
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Delayed Sleep-Wake Phase Disorder
In brief
The goal of this observational study is to characterize the pupil light response in patients with delayed sleep-wake phase disorder. A subset of participants will take part in a clinical trial to determine if increasing serotonin can alter the circadian response to light. The main questions it aims to answer is: Are there differences in the light response in patients with delayed sleep-wake phase disorder? Does citalopram increase melatonin suppression in patients with delayed sleep-wake phase disorder? Participants will complete activity and melatonin testing at home to determine their circadian timing. This will be followed by an eye test looking at the pupil response to different light stimuli. A subset of participants will complete two inpatient admissions where melatonin levels will be sampled and they will be exposed to a bright light. During one round of testing they will receive a placebo and in the other round of testing they will take a single dose of citalopram, a selective serotonin reuptake inhibitor.
Key facts
- Study ID
- NCT06949644
- Run by
- Northwestern University
- People needed
- 220
- Starts
- 2025-09-01
- Expected to finish
- 2029-08-31
- Last updated by the study team
- 2026-06-08
Who can join
Age: 16 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Delayed sleep-wake phase disorder
You may not qualify if…
- Use of medications known to alter pupil diameter
- History of eye disease or eye surgery
- Unstable medical or psychiatric condition
- Shift work or self imposed irregular sleep schedules
- Caffeine consumption >400mg/day
Where it is running
- Northwestern University — Chicago, Illinois, United States (enrolling)
Full record on ClinicalTrials.gov
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