Risk of Posterior Staphyloma in Highly Myopic Europeans : From Epidemiology to Anatomy.

Recruiting now · Not applicable

Conditions studied: High Myopia

In brief

In this cross-sectionnal study the aim is to increase the understanding of posterior staphyloma through a unique European consortium. Therefore, all eligible patients that either visit the outpatient clinic at Radboud in Nimegen, the Netherlands, or visit University Hopital Puerta de HierroMajadahonda in Madrid, Spain, or visit University Hospital Cochin in Paris, France, and after consenting, will be included. 600 high myopic European cases are expecting. A standardized protocol in all centers in order to create a uniform dataset. Besides the standard of care, blood samples will be collected. All data collected will be stored in an onlie Castor database

Key facts

Study ID

NCT06949579

Run by

Assistance Publique - Hôpitaux de Paris

People needed

200

Starts

2026-02-12

Expected to finish

2027-12-01

Last updated by the study team

2026-08-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults with high myopia (axial length ≥ 26.00 mm or degree of myopia of at least -6 diopters), with and without posterior staphyloma
• Adults aged 18 years or over
• Patient with high myopia (axial length ≥ 26.00 mm or degree of myopia of at least -6 diopters), with good quality retinal imaging
• Patient who has signed a consent form to participate in the study
• Patient who is a beneficiary of a social security scheme or who is entitled to it

You may not qualify if…

• Any systemic or ocular pathologies with an impact on the posterior segment of the eye
• Patient with a systemic pathology likely to affect the posterior segment of the eye:
• Diabetes
• Systemic inflammatory disease: sarcoidosis, rheumatoid arthritis, systemic lupus erythematosus, Horton's disease
• Patients with retinitis pigmentosa
• Patients with syndromic myopia
• Patients with myopia associated with a genetic disease such as hereditary vitreoretinopathy
• Patients under guardianship, curatorship or legal protection, as well as pregnant or breastfeeding women (article L1121-5 of the CSP).

Where it is running

• Cochin Hospital — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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