Yoga for Persistent Post-Surgical Pain (PPSP)

Recruiting now · Not applicable

Conditions studied: Persistent Post-surgical Pain

In brief

The overall goal of this project is to complete a pilot feasibility randomized controlled trial (RCT) to inform a future fully-powered translational study evaluating yoga for management and resolution of persistent-post surgical pan (PPSP) and the role of biological, psychophysical, and psychosocial modulators in PPSP resolution.

Key facts

Study ID

NCT06949007

Run by

Brigham and Women's Hospital

People needed

50

Starts

2026-03-12

Expected to finish

2029-06-30

Last updated by the study team

2026-05-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• History of torso surgeries. Examples are thoracotomy, sternotomy, mastectomy and breast implant, open abdominal surgeries, and cesarean section
• Completion of surgery alone or surgery and complementary pharmacological treatment
• Being 18 years of age or older
• 3 months with PPSP and 4/10 in BPI severity (clinically considered a moderate range)
• Access to reliable modes of transportation for study visits and yoga classes
• Confirmed access to and proficiency with use of a smartphone, computer, and/or tablet
• Fluent in English.

You may not qualify if…

• History of joint replacement, amputation, orthopedic (except thoracotomy and sternotomy), and other non-torso surgeries
• Participants with health conditions that lead to difficulty complying with study protocol (i.e., completion of outcome assessments and participation in yoga or CPHE programs), including: Renal dialysis, cognitive impairment, serious neurological or psychiatric disorders; Unstable cardiovascular disease, metastatic cancer, or serious chronic medical condition; Planned surgery during the intervention period; Chronic inflammatory systemic diseases (e.g., rheumatoid arthritis); Active acute or chronic infections requiring antibiotics; Unmanaged hearing or visual impairment affecting participation in virtual classes; Substance use disorder
• Pregnancy or having the intention to become pregnant within the next six months
• Recent (last 3 months) or concurrent participation in weekly MBMT (e.g., yoga, tai chi, qigong) programs, physical therapy, including massage and chiropractic care, or other non-pharmacological treatment as chronic pain management, such as Mindfulness-Based Stress Reduction (MBSR) or meditation
• Recent interventional pain management, defined as procedures such as corticosteroid injection, trigger point injection, and radiofrequency ablation to the cervical or lumbar region within the past 4 weeks and/or scheduled for interventional pain management procedures within the study timeframe.

Where it is running

• Mass General Brigham — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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