A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)

Running, not enrolling · Phase 3 · Has a placebo group

Conditions studied: Hypertension

In brief

The GZPL master protocol will support 2 independent studies, J2A-MC-GZL1 (GZL1) and J2A-MC-GZL2 (GZL2). The purpose of this study is to create a framework to evaluate the safety and efficacy of orforglipron for the treatment of hypertension in participants with obesity or overweight.

Key facts

Study ID

NCT06948422

Run by

Eli Lilly and Company

People needed

974

Starts

2025-04-30

Expected to finish

2027-09-01

Last updated by the study team

2026-05-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Has systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg (if DBP criteria alone is met, SBP must be ≥130 mmHg) at screening (Visit 1).
• Has SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg (if DBP criteria alone is met, SBP must be ≥130 mmHg) at week 0 (Visit 3).
• Untreated for hypertension, or on stable antihypertensive medications ≥ 30 days prior to Visit 1.
• Have a body mass index (BMI) ≥ 25 kg/m².

You may not qualify if…

• Has SBP ≥170 mmHg and/or DBP ≥110 mmHg at Visit 1 or at Visit 3.
• Has known secondary causes of hypertension
• Have heart failure with reduced ejection fraction (HFrEF) diagnosis
• Have had any of the following conditions within 90 days prior to screening.
• hospitalization for hypertension or for congestive heart failure
• acute coronary syndrome or acute myocardial infarction, or
• cerebrovascular accident (stroke).
• Have type 1 diabetes (T1D)
• Have acute or chronic hepatitis, including a history of autoimmune hepatitis

Where it is running

• Valley Clinical Trials, Inc. — Covina, California, United States
• Valley Clinical Trials, Inc. — Northridge, California, United States
• Chase Medical Research, LLC — Waterbury, Connecticut, United States
• Excel Medical Clinical Trials — Boca Raton, Florida, United States
• Care Access - Brandon — Brandon, Florida, United States
• Northeast Research Institute - Downtown Office — Jacksonville, Florida, United States
• Care Access - St. Petersburg — St. Petersburg, Florida, United States
• East-West Medical Research Institute — Honolulu, Hawaii, United States
• Sinai Hospital Of Baltimore — Baltimore, Maryland, United States
• Ascension Saint Agnes Heart Care — Baltimore, Maryland, United States
• Lucida Clinical Trials — New Bedford, Massachusetts, United States
• Arcturus Healthcare , PLC, Troy Internal Medicine Research Division — Troy, Michigan, United States
• StudyMetrix Research — City of Saint Peters, Missouri, United States
• Excel Clinical Research, LLC — Las Vegas, Nevada, United States
• Palm Research Center Sunset — Las Vegas, Nevada, United States
• Rochester Clinical Research, LLC — Rochester, New York, United States
• Remington-Davis, Inc — Columbus, Ohio, United States
• PriMED Clinical Research — Dayton, Ohio, United States
• Advanced Research Institute - Tigard — Tigard, Oregon, United States
• Care Access - Mauldin — Mauldin, South Carolina, United States
• Dallas Heart and Vascular Consultants, PA — Duncanville, Texas, United States
• Texas Institute of Cardiology, PA — McKinney, Texas, United States
• North Hills Family Medicine/North Hills Medical Research — North Richland Hills, Texas, United States
• Advanced Research Institute — Ogden, Utah, United States
• Elite Clinical Studies, LLC — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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