Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy

Recruiting now · Not applicable

Conditions studied: Smoking Cessation, Obesity and Obesity-related Medical Conditions

In brief

This project will investigate the effects of alternative nicotine products on smoking, weight gain, and related outcomes.

Key facts

Study ID

NCT06948058

Run by

Brown University

People needed

60

Starts

2025-04-01

Expected to finish

2027-08-31

Last updated by the study team

2026-05-18

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• body mass index (BMI) ≥ 30 kg/m2 (i.e., obese)
• smoked ≥ 5 cigarettes/day during the past year
• 21 or older (due to minimum legal age EC restrictions)
• exhaled breath carbon monoxide (CO) level > 6 ppm at Baseline (BL) (to confirm self-reported smoking)
• willing to use EC or NRT for 8 weeks
• access to a Bluetooth-enabled smartphone/tablet (to permit remote measurement of CO and other outcome variables)

You may not qualify if…

• received smoking cessation treatment of any kind in the past 30 days (actively quitting smoking),
• currently using EC or NRT more than 2 days/week (this may affect responses to study-supplied products)
• hospitalized for mental illness in past 30 days
• heart-related event (e.g., heart attack, severe angina) in past 30 days
• residing with another person currently enrolled in the study
• pregnant, nursing, or planning to become pregnant in the next 6 months
• medical contraindication for study or product use (e.g., allergy to adhesives)
• taken prescription weight loss medication in the last 30 days

Where it is running

• Brown University — Providence, Rhode Island, United States (enrolling)

Full record on ClinicalTrials.gov

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