Immunological Aspect of Thrombotic Thrombocytopenic Purpura (TTP)

Recruiting now

Conditions studied: Thrombotic Thrombocytopenic Purpura (TTP)

In brief

The general objective of the proposed project is to characterise phenotypically and functionally ADAMTS13-specific memory B lymphocytes and autoreactive T lymphocytes, in particular follicular helper T lymphocytes, in the acute phase of the disease, but also during its progression after treatment. The aim is to highlight their contribution to the initial pathogenic process, their evolution under treatment, and also their involvement in patients who are refractory to immunosuppressive therapies and during relapses. The aim of this project is to identify early phenotypic or functional parameters that are predictive of relapse and that can be used for personalised optimisation of treatment to maintain remission.

Key facts

Study ID

NCT06945861

Run by

University Hospital, Rouen

People needed

44

Starts

2023-05-11

Expected to finish

2028-05-11

Last updated by the study team

2026-05-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age over 18
• patients with TTP at any stage of diagnosis (acute phase, lasting remission or not, relapse)
• patients undergoing internal medicine at Rouen University Hospital
• people who have read and understood the information letter
• membership of a social security scheme

You may not qualify if…

• a person deprived of liberty by an administrative or judicial decision or a person placed under court protection/guardianship or guardianship

Where it is running

• University Rouen Hospital, — Rouen, France (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.