A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes

Running, not enrolling · Phase 1 · Has a placebo group

Conditions studied: Healthy, Overweight, Obesity, Type 2 Diabetes

In brief

The main purpose of this study is to evaluate the safety, tolerability of LY4086940 and how it is processed in the body. Participation in Part A of the study will last about 10 weeks and may include up to 6 visits. Participation in Parts B, C, D will last approximately 15 weeks and may include up to 10 visits. Participation in Part E will last approximately 7 weeks and may include up to 12 visits.

Key facts

Study ID

NCT06945419

Run by

Eli Lilly and Company

People needed

216

Starts

2025-04-23

Expected to finish

2026-08-01

Last updated by the study team

2026-06-16

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Have no significant body weight change for the 3 months prior to screening
• Part A and Part E:
• Are considered healthy
• Have a body mass index (BMI) of 22 to 35 kilograms per square meter (kg/m2) at screening
• Part B:
• Have a BMI of 27 to 45 kg/m2 at screening
• Part C:
• Have a BMI of 25 to 45 kg/m2 at screening
• Part D:
• Have type 2 diabetes
• Have hemoglobin A1C (HbA1c) ≥6.5% and ≤10.5% at screening
• Have a BMI of 27 to 45 kg/m2 at screening

You may not qualify if…

• Have had an acute cardiovascular condition within the past 6 months prior to screening
• Have liver disease or pancreatitis
• Have used medications for weight loss within the 3 months prior to screening
• Parts A, B, C, E:
• Have any form of diabetes
• Part D:
• Have type 1 diabetes

Where it is running

• Fortrea Clinical Research Unit — Daytona Beach, Florida, United States
• Clinical Pharmacology of Miami — Miami, Florida, United States
• Fortrea Clinical Research Unit — Dallas, Texas, United States
• Endeavor Clinical Trials — San Antonio, Texas, United States
• Lilly Centre for Clinical Pharmacology — Singapore, Singapore

Full record on ClinicalTrials.gov

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