Comparative Study of Three Collagen Membranes: 1 Non-cross-linked and 2 Cross-linked

Completed · Not applicable

Conditions studied: Bone Regeneration

In brief

This study is being done to compare how quickly three different types of collagen membranes break down when they are exposed to the mouth. These membranes are often used in dental and oral surgery to help with healing and tissue growth. The goal is to find out if one membrane lasts longer than the others, which may help doctors choose the best option for different procedures. In this study, the membranes will be placed in the mouth in a specific area near the gums of the upper back teeth. The study is designed so that neither the patients nor the researchers evaluating the results will know which membrane is which (this is called a double-blind study). Over time, researchers will measure how much each membrane has broken down. This information may help improve treatment planning and patient outcomes in dental care.

Key facts

Study ID

NCT06944639

Run by

Andrea Ravida

People needed

25

Starts

2025-04-28

Expected to finish

2026-06-25

Last updated by the study team

2026-08-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• ≥ 18 years old
• Good overall health (ASA I or ASA II)
• Good oral health

You may not qualify if…

• Patients with gingival pathologies
• Individuals with uncontrolled chronic diseases or immunocompromised.
• Pregnant Patients
• Patients who are currently breastfeeding

Where it is running

• University of Pittsburgh, School of Dental Medicine — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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