Oxalate and Citrate in Humans - Response to Citrate

Recruiting now · Not applicable

Conditions studied: Kidney Stone, Healthy

In brief

This is a single-center study that aims to learn more about how two compounds found in food, oxalate and citrate, interact in the body and may influence a person's chances of forming kidney stones. The study will examine changes in urinary oxalate and citrate levels after participants consume potassium citrate.

Key facts

Study ID

NCT06944223

Run by

University of Chicago

People needed

24

Starts

2025-10-01

Expected to finish

2027-06-01

Last updated by the study team

2025-12-16

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Stone formers (SF):
• Age 18-70
• History of at least one calcium-based kidney stone
• Non-stone formers (NSF):
• Age 18-70
• No history of kidney stone
• 24-hour urine oxalate within laboratory normal range (<50 mg/day)

You may not qualify if…

• History of primarily uric acid, cysteine, or struvite stones
• History of severe acid-base abnormality, very low (less than 100 mg/day) or very high (greater than 1500 mg/day) urine citrate
• Any controls or stone former (SF) participants who cannot stop diuretic medication or alkali supplementation for the course of the study period
• Chronic kidney disease (glomerular filtration rate <75 milliliters per minute per 1.73 square meters [mL/min/1.73 m²])
• Non-stone formers (NSF) and stone formers (SF) with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.

Where it is running

• University of Chicago Medical Center — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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