Evaluation of the Antioxidant and Anti-Inflammatory Capacities of the 'Rosy Red Valencia' and 'Olinda Valencia' Sweet Orange Varieties in Healthy Subjects

Completed · Not applicable

Conditions studied: Healthy

In brief

This study aims to evaluate the antioxidant and anti-inflammatory effects of acute and chronic consumption of two sweet orange (Citrus sinensis) varieties-'Rosy Red Valencia', which is rich in carotenoids such as lycopene, phytoene, and phytofluene, and 'Olinda Valencia', which lacks these carotenoids-in healthy adults. In this 4-week, randomized, parallel-arm clinical trial, participants will consume either 'Rosy Red Valencia' or 'Olinda Valencia' oranges daily. The study will assess the effects of sweet orange intake on markers of oxidative stress and inflammation, plasma carotenoid concentrations, gene expression in peripheral blood mononuclear cells, and gut health. Findings from this study may help identify potential health benefits associated with specific carotenoid profiles in sweet oranges and provide insights into their role in modulating inflammation and oxidative stress.

Key facts

Study ID

NCT06944210

Run by

University of California, Davis

People needed

20

Starts

2025-05-17

Expected to finish

2026-03-06

Last updated by the study team

2026-03-11

Who can join

Age: 25 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy men and women
• Age Range: 25-40 years
• Body mass index (BMI) with values between 21 and 29.9 kg\^m2
• Willingness to accept randomization, undergo the testing and intervention procedures, and deliver blood and stool samples
• Willingness to refrain from consuming foods rich in lycopene, phytoene, and phytofluene and limit the intake of some polyphenol-rich foods
• Willingness to discontinue the use of antioxidant supplements (such as carotenoid, polyphenol supplements), prebiotics and/or probiotics

You may not qualify if…

• Pregnancy/lactation
• History of cardiovascular diseases, diabetes, uncontrolled hypertension, heart failure, stroke, liver, gallbladder, kidney, thyroid disease, gastrointestinal, autoimmune disorder, or cancer.
• Psychiatric disease that interferes with the understanding and implementation of the intervention
• History of eating disorders (such as bulimia nervosa and anorexia nervosa) in the last 5 years
• Current smokers
• Vegan, vegetarian, or other special diets (e.g., keto, paleo)
• Use of antibiotics or laxatives in the previous month
• History of substance abuse or alcohol abuse
• involvement in a weight loss intervention program within the past month or weight change > 10%
• Self-report of allergic reactions to study products or their phytochemicals.

Where it is running

• Nutrition Department, Ragle Facility, University of California Davis — Davis, California, United States

Full record on ClinicalTrials.gov

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