Platelet-Rich Fibrinogen in Extraction Socket Healing of the Aged

Recruiting now · Not applicable

Conditions studied: Edentulism

In brief

The purpose of this study is to better understand oral wound healing in the aged participant following placement of platelet-rich fibrinogen (PRF). In this study, 12 participants requiring a posterior tooth extraction will be enroll: 6 participants aged 14-18, 6 participants aged 50-80. All will undergo a posterior tooth extraction with a small tissue specimen taken from the extraction site. Half of the participants will also have their blood drawn and platelet-rich fibrinogen placed in the extraction socket. Participants will return in 2 weeks for suture removal and another soft tissue sample. Participants will return at 3 months for a final post-operative radiograph. All soft tissue samples will undergo immunofluorescence.

Key facts

Study ID

NCT06943846

Run by

University of Nebraska

People needed

12

Starts

2025-05-01

Expected to finish

2027-05-01

Last updated by the study team

2026-01-27

Who can join

Age: 14 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient at University of Nebraska Medical Center (UNMC) College of Dentistry
• Requires extraction of posterior tooth
• Able and willing to provide consent/assent

You may not qualify if…

• Systemic conditions that delay wound healing
• Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs), methotrexate, bisphosphonates or other drugs that inhibit wound healing Smoking and vaping Pregnancy

Where it is running

• University of Nebraska Medical Center College of Dentistry — Lincoln, Nebraska, United States (enrolling)

Full record on ClinicalTrials.gov

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