Effect of Partially Hydrolyzed Formula With Synbiotics on Skin Barrier Function
Recruiting now · Not applicable
Conditions studied: Atopic Dermatitis (AD)
In brief
The main purpose of this study is to assess the efficacy of a partially hydrolyzed formula with synbiotics in halting one of the first steps of the allergic march (atopic dermatitis) in infants at risk of allergy. Other efficacy and safety parameters will be assessed as well.
Key facts
- Study ID
- NCT06943469
- Run by
- Société des Produits Nestlé (SPN)
- People needed
- 400
- Starts
- 2025-04-10
- Expected to finish
- 2028-11-01
- Last updated by the study team
- 2026-07-30
Who can join
Age: 0 and older, up to 0. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Written informed consent has been obtained from at least one parent or legally acceptable representative (LAR), if applicable
- Infant gestational age ≥ 37 completed weeks
- Infant birth weight of ≥ 2.5 kg and ≤ 4.5 kg
- Infant postnatal age ≤ 14 days (date of birth = day 0) at enrollment
- Infant from singleton birth or infant from multiple births may if all birth siblings are enrolled.
- At least one biological parent or sibling has (or had) a medically diagnosed history of allergy, based on response to a simple screening questionnaire
- a. For the breastfed reference group only: infant is exclusively breastfed since birth with no intake of formula, and their parent(s) have the intention to continue exclusive breastfeeding until at least 4 months of age.
- or b. For the randomized formula-fed groups only: infant is exclusively or predominantly formula-fed in the 24 hours prior to enrollment, with formula feeding representing at least 75% of total daily feeds. The decision to introduce formula feeding was independently made by the parents before enrollment.
- Parents/LAR must be able to provide evidence of parental authority and identity.
- Infant's parent(s)/LAR must understand the informed consent form and other study documents and are willing and able to fulfill the requirements of the study protocol.
You may not qualify if…
- Infectious, metabolic, congenital, genetic, gastrointestinal illness or any other condition (e.g., gastrointestinal surgery) that could impact oral feeding, growth or study outcomes.
- Infants with special dietary needs other than standard infant formula (e.g., extensively hydrolyzed formula, amino acid formula, special formula for metabolic diseases) or requiring tube feeding.
- Infant has already been diagnosed with allergy by a physician, including AD and/or cow's milk allergy.
- Infant is currently participating or has previously participated in another clinical trial prior to enrollment.
- Infant's parents or LARs have not reached legal age of majority (18 years).
Where it is running
- HCU Lozano Blesa — Zaragoza, Spain (enrolling)
- Hospital Quiron Salud Barcelona — Barcelona, Spain (enrolling)
- Hospital Universitario Severo Ochoa — Madrid, Spain (enrolling)
- Grupo Pediátrico Uncibay — Málaga, Spain (enrolling)
- Hospital Universitari de Tarragona Joan XXIII — Tarragona, Spain (enrolling)
- Hospital Universitari Sant Joan de Reus — Tarragona, Spain (enrolling)
- AZ Sint-Jan Brugge-Oostende AV - Campus Sint-Jan — Bruges, Belgium (enrolling)
- Clinique Ste Elisabeth — Namur, Belgium (enrolling)
- CHU Amiens Picardie — Amiens, France (enrolling)
- CHU de Caen — Caen, France (enrolling)
- Hôpital de la Croix Rousse — Lyon, France (enrolling)
- Hôpital Charles Nicolle — Rouen, France (enrolling)
- CHRU de Tours — Tours, France (enrolling)
- Evangelisches Krankenhaus Düsseldorf - Frauenklinik — Düsseldorf, Germany (enrolling)
- Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Frankfurt — Frankfurt, Germany (enrolling)
- Evangelisches Waldkrankenhaus Spandau — Spandau, Germany (enrolling)
- Marien Hospital Wesel GmbH — Wesel, Germany (enrolling)
- Hospital Teresa Herrera — A Coruña, Spain (enrolling)
- HU Torrecárdenas — Almería, Spain (enrolling)
- Universitair Ziekenhuis Brussel - Kinderziekenhuis — Brussels, Belgium
- Prywatna Praktyka Lekarska Gabinet Pediatryczno-Alergologiczny — Bialystok, Poland
- BioMedical Centers — Warsaw, Poland
- Charite-Universitaetsmedizin Berlin - Campus Virchow-Klinikum (CVK) — Berlin, Germany
- CHU de Grenoble Alpes — Grenoble, France
- Instituto Hispalense de Pediatria (IHP) — Seville, Spain
Full record on ClinicalTrials.gov
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