A Study to Evaluate the Effect of Formulation and Food on Calderasib (MK-1084) in Healthy Adult Participants (MK-1084-011)

Completed · Phase 1

Conditions studied: Healthy

In brief

This study has 2 parts. Researchers want to learn what happens to calderasib in a healthy person's body over time in both parts. The goals of the study are: * In Part 1, to compare what happens to calderasib in a person's blood when it is taken as 2 different types of oral tablets * In Part 2, to learn what happens to calderasib in a person's blood when it is taken on an empty stomach or after a meal

Key facts

Study ID

NCT06942741

Run by

Merck Sharp & Dohme LLC

People needed

52

Starts

2025-05-13

Expected to finish

2025-08-04

Last updated by the study team

2026-02-11

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• The main inclusion criteria include but are not limited to the following:
• Has a body mass index ≥18.0 and ≤32.0 kg/m\^2

You may not qualify if…

• The main exclusion criteria include but are not limited to the following:
• Has a history or presence of a clinically significant medical or psychiatric condition or disease
• Has a history of cancer (malignancy)
• Has positive results for human immunodeficiency virus, hepatitis B surface antigen, or hepatitis C virus

Where it is running

• Celerion ( Site 0001) — Tempe, Arizona, United States

Full record on ClinicalTrials.gov

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