Determination of the Optimal Volume of Liposomal Bupivacaine in Adductor Canal Block for Knee Joint Surgery

Recruiting now · Phase 4

Conditions studied: Optimal Volume of Liposomal Bupivacaine

In brief

Building on Bayesian design methodologies from volume optimization studies of ropivacaine in shoulder surgery, this study pioneers the application of a seamless dose-finding strategy in knee ACB. Utilizing advanced statistical models (BOIN/BOP2 design), we aim to systematically evaluate the volume-effect relationship of liposomal bupivacaine, providing precise dosing recommendations to advance personalized and optimized analgesic protocols for knee surgery.

Key facts

Study ID

NCT06942689

Run by

Nanjing First Hospital, Nanjing Medical University

People needed

63

Starts

2025-06-01

Expected to finish

2027-12-31

Last updated by the study team

2025-09-08

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing elective general anesthesia for unilateral knee joint surgery.
• Patients who provide informed consent.
• Aged between 18 and 65 years old, regardless of gender.
• American Society of Anesthesiologists (ASA) physical status classification of Ⅰ to Ⅲ
• Body mass index (BMI) ≤ 35 kg/m².

You may not qualify if…

• Femoral neuropathy.
• Coagulation dysfunction.
• Allergy to local anesthetics.
• Infection at the puncture site.
• History of chronic pain or opioid use.
• Pregnancy.
• Diabetes mellitus and peripheral neuropathy.

Where it is running

• Nanjing First Hospital — Nanjing, Jiangsu, China (enrolling)

Full record on ClinicalTrials.gov

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