Phase 2 Trial of RGX-314 in Adults With Center Involved - Diabetic Macular Edema (CI - DME)

Recruiting now · Phase 2

Conditions studied: Diabetic Macular Edema

In brief

Phase 2 open label, randomized, active controlled, dose-ranging trial in adults with Center Involved - Diabetic Macular Edema (CI - DME)

Key facts

Study ID

NCT06942520

Run by

Sierra Eye Associates

People needed

18

Starts

2025-03-18

Expected to finish

2027-12-01

Last updated by the study team

2025-04-24

Who can join

Age: 25 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Type I or Type II diabetes mellitus with center involving diabetic macular edema with previous treatment
• HbA1c ≤12%
• BCVA in study eye 78 to 25 ETDRS letters (\~20/32 to 20/320) at screening
• Decreased visual acuity attributable primarily due to CI - DME
• Demonstrate clinical response to aflibercept injection in the study eye
• Provide written informed consent

You may not qualify if…

• Women of childbearing potential
• Neovascularization in the study eye from a cause other than DR
• Evidence in the study eye of optic nerve pallor on clinical examination
• History of pan retinal photocoagulation in the study eye
• Any concurrent ocular condition in the study eye other than CI-DME that could require surgical intervention within 6 months or any condition in the study eye that may increase the risk to the participant, require either medical or surgical intervention during the study to prevent or treat vision loss, or interfere with the study procedures or assessments
• Presence of an implant in the study eye at screening (excluding intraocular lens)
• Any condition in the investigator's opinion that could limit VA improvement in the study eye
• Active or history of glaucoma, steroid response, or ocular hypertension
• Any prior intravitreal steroid injection in the study eye within 6 months prior to screening, administration in the study eye of Ozudrex® within 12 months prior to screening, or administration in the study eye if Iluven® within 36 months prior to screening
• Diabetic macular edema diagnosis ≥ 7 years
• History of chronic renal failure requiring dialysis or kidney transplant
• Participation in any other gene therapy study or receipt of any investigational product within 30 days prior to enrollment or 5 half-lives of the investigational product, whichever is longer, or any plans to use an investigational product within 6 months following enrollment
• Note: Other inclusion/exclusion criteria apply

Where it is running

• Sierra Eye Associates — Reno, Nevada, United States (enrolling)

Full record on ClinicalTrials.gov

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