iTBS for Acute Ischemic Stroke After Thrombectomy
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Ischemic Stroke
In brief
The goal of this randomized, single-blind, parallel-controlled clinical trial is to evaluate the efficacy and safety of intermittent theta burst stimulation (iTBS) as an adjunctive therapy for acute anterior circulation ischemic stroke patients who have undergone successful mechanical thrombectomy (MT). The study population includes adults aged 18-85 with NIHSS scores 5-25 post-MT and eTICI≥2b reperfusion.
Key facts
- Study ID
- NCT06941961
- Run by
- Yi Yang
- People needed
- 178
- Starts
- 2025-04-25
- Expected to finish
- 2026-08-01
- Last updated by the study team
- 2025-04-30
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 1) Age 18-85 years, regardless of gender.
- 2) Acute ischemic stroke caused by occlusion of the anterior circulation large vessels (internal carotid artery, M1 or M2 segment of the middle cerebral artery), verified by CTA or DSA.
- 3) Mechanical thrombectomy (MT) performed within 24 hours of symptom onset.
- 4) Successful Reperfusion: Post-MT eTICI score ≥ 2b.
- 5) NIHSS score 5-25 at 24 hours post-MT, with ≥2 points in at least one limb.
You may not qualify if…
- 1) Pre-stroke modified Rankin Scale (mRS) score ≥2.
- 2) PH2-type intracranial hemorrhage on brain CT post-MT.
- 3) Patients who underwent intracranial stent placement during MT.
- 4) Contraindications to iTBS: History of epilepsy or seizures, implanted cardiac pacemakers, cochlear implants, or other electronic/magnetic-sensitive devices.
- 5) Severe consciousness impairment, cognitive dysfunction, or psychiatric disorders preventing compliance with iTBS.
- 6) Expected survival <3 months due to other medical conditions or inability to complete follow-up for any reason.
- 7) Participation in another interventional study.
- 8) Any other condition deemed unsuitable for enrollment by the investigator.
Where it is running
- The First Hospital of Jilin University — Changchun, Jilin, China (enrolling)
Full record on ClinicalTrials.gov
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