Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their Caregivers
Enrolling by invitation · Not applicable
Conditions studied: Alzheimer Disease, Dementia, Mild Cognitive Impairment, Peer-bonded Caregiver, Caregiver
In brief
This study aims to investigate the neurophysiological effects of live music on individuals with early Alzheimer's Disease (AD), dementia, and/or mild cognitive impairment (MCI) and their caregivers. Heart rate (HR), heart rate variability (HRV), and brain activity will be measured as participant-caregiver dyads listen to preferred and improvised music performed by professional musicians. Investigators will leverage various measurement techniques including, but not limited to, electroencephalography (EEG), behavioral, surveys, and physiological monitoring to study the impact of live music on anxiety in AD and inter-dyad synchrony.
Key facts
- Study ID
- NCT06940687
- Run by
- Yale University
- People needed
- 60
- Starts
- 2025-01-28
- Expected to finish
- 2026-03-22
- Last updated by the study team
- 2026-02-11
Who can join
Age: 50 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Clinical Dementia Rating 0.5 - 2
- Be a person with or caregiver to a person with a diagnosis of early Alzheimer's Disease, mild dementia, and/or mild cognitive impairment (MCI)
- Able to provide informed consent
- Willing to wear an EEG headset and heart rate monitoring devices
- Willing to possibly have small patches of body / facial hair shaved to accommodate administration of heart rate monitoring devices
- Willing to answer survey questions about topics related to the study
- Willing to be audio / video recorded
You may not qualify if…
- Clinical Dementia Rating <0.5 or > 2
- Unable to provide informed consent
- Endorsing suicidal ideation (SI), self-injurious behavior, or homicidal ideation (HI) above the threshold defined in the "Risk Reduction and Safety Plan"
- Participating in another clinical trial studying AD and/or Dementia
- Starting a new prescription medication in the last 6 months
- Prescribed Benzodiazepines on an as needed basis
Where it is running
- Firehouse 12 Studios — New Haven, Connecticut, United States
- Musical Intervention Studios — New Haven, Connecticut, United States
Full record on ClinicalTrials.gov
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