Addressing Medication Non-adherence in Patients With Poorly Controlled Hypertension Using Urine Mass Spectrometry
Recruiting now · Not applicable
Conditions studied: Hypertension, Uncontrolled Hypertension, Non-Adherence, Medication
In brief
* Hypertension is the single largest contributor to cardiovascular disease and death. While adequate control of hypertension reduces risk of disease, many patients have uncontrolled hypertension. This is often due to medication non-adherence. Left undetected, patients are prescribed additional medications, and referred to multiple specialists for investigations - leading to increased healthcare costs. Hence, detecting non-adherence to antihypertensive medications is important. However, patient history, patient recall, or questionnaires, are often inaccurate. Most recently, urine measurements of antihypertensive drug levels, using mass spectrometry, has been established as the gold standard to assess medication adherence. The one-time urine test for medication adherence is ideal: It's convenient, non-invasive, economical, and can be easily performed in a clinic setting. By improving blood pressure control, this will lead to reductions in healthcare visits, avoidance of catastrophic cardiovascular events. Ultimately, this translates to significant economic savings for both patients with hypertension and the healthcare system. * Therefore, the investigators hypothesize that the implementation of urine adherence testing coupled with targeted counselling will improve the adherence and blood pressure control in hypertension. To do this, the investigators aim to (1) evaluate for medication adherence in 312 participants with recent stroke and hypertension; (2) evaluate for medication non-adherence in participants with uncontrolled hypertension; and (3) assess if detection of non-adherence can improve hypertension control.
Key facts
- Study ID
- NCT06938633
- Run by
- Changi General Hospital
- People needed
- 100
- Starts
- 2024-02-07
- Expected to finish
- 2025-09-30
- Last updated by the study team
- 2025-04-22
Who can join
Age: 21 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age of 21 - 80 years
- Systolic blood pressure of ≥140 mmHg or average systolic blood pressure ≥135 mmHg, or diastolic blood pressure ≥90 mmHg or average diastolic blood pressure ≥85 mmHg, on at least two measurements
- Currently taking 2 or more hypertension medications
- Able to provide informed consent.
You may not qualify if…
- Significant kidney impairment with eGFR of less than 45mL/min/1.73m2 or on dialysis
- Known history of chronic liver disease
Where it is running
- Changi General Hospital — Singapore, Singapore (enrolling)
Full record on ClinicalTrials.gov
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