Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.

Recruiting now · Not applicable

Conditions studied: Polyp of Colon, Endoscopic Mucosal Resection

In brief

The goal of this randomized clinical trial is to learn if a combination of hot and cold EMR technique is associated with a lower risk of polyp recurrence without increasing the risk of complication when removing large polyps. Participants will undergo EMR and return for a follow-up endoscopy in 3-6 months to check for polyp recurrence.

Key facts

Study ID

NCT06937671

Run by

The Cleveland Clinic

People needed

194

Starts

2025-05-01

Expected to finish

2026-12-01

Last updated by the study team

2026-07-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patient (age 18 years or older)
• Polyp size of at least 20 mm
• - Morphology: Flat or superficially raised polyp morphology (i.e., Paris classification 1s, 0-IIa or 0-IIb, or a combination of the above)

You may not qualify if…

• Polyps with previous failed resection attempts or polyp recurrence
• Suspected deep submucosal invasion on endoscopic assessment of surface mucosal pit pattern (Kudo V or NICE 3 pattern) or histologically confirmed malignancy (invasive adenocarcinoma)
• Polyps with nodules too large (>1-1.5cm) for the use of a cold snare
• Inflammatory bowel disease

Where it is running

• Cleveland Clinic Weston — Weston, Florida, United States (enrolling)
• Cleveland Clinic — Cleveland, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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