ONO-4538 Study in Patients With Richter's Transformation

Recruiting now · Phase 2

Conditions studied: Richter's Transformation

In brief

Investigate the efficacy and safety of ONO-4538 in patients with Richter's transformation

Key facts

Study ID

NCT06936943

Run by

Ono Pharmaceutical Co., Ltd.

People needed

14

Starts

2025-11-19

Expected to finish

2030-07-31

Last updated by the study team

2026-02-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histological diagnosis of diffuse large B-cell lymphoma (DLBCL)-type or Hodgkin lymphoma(HL)-type Richter's transformation with a history of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)
• In the case of DLBCL-type Richter's transformation, refractory, intolerant or ineligible for treatment of DLBCL
• Patients with measurable disease
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
• Expected to survive for 90 days or more

You may not qualify if…

• Serious complications
• Active multiple cancers
• Active central nervous system (CNS) disease
• History of allogeneic hematopoietic stem cell transplantation

Where it is running

• Aichi Cancer Center — Nagoya, Aichi-ken, Japan (enrolling)
• Kyusyu University Hospital — Fukuoka, Fukuoka, Japan (enrolling)
• Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital — Hiroshima, Hiroshima, Japan (enrolling)
• Hokkaido University Hospital — Sapporo, Hokkaido, Japan (enrolling)
• Kyoto University Hospital — Kyoto, Kyoto, Japan (enrolling)
• Tohoku University Hospital — Sendai, Miyagi, Japan (enrolling)
• Niigata University Medical & Dental Hospital — Niigata, Niigata, Japan (enrolling)
• Kindai University Hospital — Ōsaka-sayama, Osaka, Japan (enrolling)
• Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital — Bunkyō-Ku, Tokyo, Japan (enrolling)
• National Cancer Center Hospital — Chuo Ku, Tokyo, Japan (enrolling)

Full record on ClinicalTrials.gov

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