OSNA Versus Ultrastaging to Detect Sentinel Lymph Node Metastasis in Endometrial Cancer

Recruiting now · Not applicable

Conditions studied: Endometrial Cancer

In brief

Patients enrolled in the study will be randomized before surgery: in one study arm, the search for lymph node metastases in surgically removed sentinel lymph nodes will occur using the ultrastaging method (standard), while in the other arm it will be conducted using the OSNA method.

Key facts

Study ID

NCT06935305

Run by

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

People needed

1922

Starts

2025-07-30

Expected to finish

2029-03-17

Last updated by the study team

2025-11-18

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed endometrial cancer
• Apparent (pre-operative) FIGO stage I-II
• Radical surgery
• Attempt of SLN mapping

You may not qualify if…

• Uterine sarcoma (including endometrial stromal sarcoma)
• Fertility sparing surgery
• Dedifferentiated histology
• Undifferentiated histology
• Neoadjuvant therapy
• Previous surgery to pelvic lymph nodes
• Lymph nodes with short axis >15 mm at pre-operative imaging

Where it is running

• Fondazione Policlinico Universitario Agostino Gemelli IRCCS — Rome, Italy, Italy (enrolling)

Full record on ClinicalTrials.gov

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