Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis
Recruiting now · Not applicable
Conditions studied: Brain Metastases
In brief
This multicentre proof-of-concept study, involving 4 centers, aims to establish the value of fractionated neoadjuvant stereotactic radiotherapy (NaSRT) as a new treatment paradigm for brain metastases (BM) in the frame of the Czech neurooncology network. Most relevant studies published to date used single-fraction radiotherapy and dealt with the inherent bias related to their retrospective nature. The researchers aim to increase the level of evidence for this treatment paradigm together with other similar ongoing studies.
Key facts
- Study ID
- NCT06933199
- Run by
- University Hospital Ostrava
- People needed
- 260
- Starts
- 2025-05-01
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2025-05-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years
- Karnofsky Performance Status ≥ 60
- Histologically verified primary cancer disease
- MRI findings indicating BM
- Target BM indicated for surgical resection and any other metastases suitable for radical SRT.
- Target BM between 1 cm and 7 cm at the longest diameter on T1 post-contrast MR imaging
You may not qualify if…
- Confirmed hematological malignity
- Small-cell (lung) carcinoma
- Peracute condition requiring immediate neurosurgical intervention
- History of whole-brain radiotherapy (WBRT)
- History of stereotactic radiotherapy to a target brain metastasis
- Pregnancy
- Inability to perform surgical resection of the target BM within 7 days after NaSRT
Where it is running
- University Hospital Ostrava — Ostrava, Moravian-Silesian Region, Czechia (enrolling)
- Masaryk Memorial Cancer Institute — Brno, Czechia (enrolling)
- University Hospital Hradec Králové — Hradec Králové, Czechia (enrolling)
- University Hospital Olomouc — Olomouc, Czechia (enrolling)
Full record on ClinicalTrials.gov
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