The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% FAO in the Management of Oral Lichen Planus
Recruiting now · Not applicable
Conditions studied: Oral Lichen Planus
In brief
This randomized, double-blind clinical trial evaluates the therapeutic effects of curcumin in nanogels compared to 0.1% fluocinolone acetonide oral paste in the management of atrophic-erosive oral lichen planus (OLP). The study aims to determine whether curcumin nanogels, a natural treatment with enhanced bioavailability, are as effective and better tolerated than standard corticosteroid therapy.
Key facts
- Study ID
- NCT06932848
- Run by
- Chulalongkorn University
- People needed
- 30
- Starts
- 2025-06-01
- Expected to finish
- 2026-06-30
- Last updated by the study team
- 2026-03-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 years or older
- Ability to provide written informed consent
- Clinically and histopathologically confirmed diagnosis of erosive or atrophic oral lichen planus (OLP)
- Presence of symptoms (NRS pain score > 0 at baseline)
- Ability to communicate and follow instructions
- Willingness to apply oral paste treatment and comply with study protocol
You may not qualify if…
- Pregnancy or lactation
- Current orthodontic treatment
- Uncontrolled diabetes mellitus (HbA1c > 7% or FPG > 130 mg/dL)
- Use of anticoagulants or antiplatelet agents
- Severe dry mouth (Challacombe score > 7)
- History of gastric ulcers, duodenal ulcers, or gallstones
- Presence of any active malignancy or infection
- Use of topical/systemic treatment for OLP in the past 2 weeks
- Current use of immunosuppressants
- Known allergy to corticosteroids or herbal agents such as turmeric
- Diagnosis of oral lichenoid contact lesion or graft-versus-host disease (GVHD)
- History of allogeneic bone marrow transplantation
- Current smokers
Where it is running
- Faculty of Dentistry, Chulalongkorn University — Bangkok, Thailand (enrolling)
Full record on ClinicalTrials.gov
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