Suicide Preventive Psychosocial Treatment for Youths

Recruiting now · Not applicable

Conditions studied: Suicide Attempt, Suicidal and Self-injurious Behavior, Suicide Attempted, Suicide, Attempted

In brief

Suicide is the leading cause of death amongst 10-18-year-olds in Sweden. Suicide attempts are the strongest predictor of subsequent death by suicide, often lead to inpatient care, and are associated with substantial societal costs, making suicide attempts a critical target in psychiatric intervention research. Although youths attempting suicide are typically assessed and treated for potential comorbid psychiatric conditions, there is currently no trans-diagnostic evidence-based treatment specifically targeting suicidal behavior. To fill this gap, the Safe Alternatives for Teens and Youths (SAFETY) was developed. SAFETY is a transdiagnostic family-based cognitive-behavioral suicide prevention program that has shown promise but more studies are needed. The overall objective of this project is to evaluate the efficacy, durability, and cost-effectiveness of the SAFETY intervention, a scalable suicide prevention intervention that can be offered immediately following a youth suicide attempt, in a fully powered single-blind randomized controlled superiority trial. Our primary hypothesis is that the SAFETY intervention will be superior to Enhanced Treatment As Usual (enhanced with the evidence-based intervention safety planning) in reducing the proportion of suicide reattempts. Moreover, we predict that these improvements will be maintained for up to 60 months post-treatment. Finally, we expect that SAFETY will be cost-effective compared to the control intervention, both at the primary endpoint and in the longer term.

Key facts

Study ID

NCT06931639

Run by

Karolinska Institutet

People needed

282

Starts

2025-05-28

Expected to finish

2032-09-01

Last updated by the study team

2026-04-17

Who can join

Age: 10 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Symptoms obstructing participation in assessments or treatment
• Insufficient understanding of the Swedish language in youth and/or caregiver
• Enrolled in Dialectical Behavioral Therapy

Where it is running

• Child and Adolescent Mental Health Services, Region Skåne — Helsingborg, Sweden (enrolling)
• Child and Adolescent Mental Health Services, Region Halland — Kungsbacka, Sweden (enrolling)
• Child and Adolescent Mental Health Services, Region Stockholm — Stockholm, Sweden (enrolling)
• Child and Adolescent Psychiatry, Region Uppsala — Uppsala, Sweden (enrolling)
• Child and Adolescent Psychiatry, Region Värmland — Karlstad, Sweden

Full record on ClinicalTrials.gov

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