Liquid Biopsy-Based Novel Modality for Postoperative Management of Lung Cancer

Recruiting now · Not applicable

Conditions studied: Non-small Cell Lung Cancer, Minimal Residual Disease, Adaptive Treatment

In brief

The goal of this study is to develop new techniques for minimal residual disease(MRD) monitoring and to confirm the efficacy and safety of MRD-guided postoperative management for early stage non-small cell lung cancer. The main questions this study aims to answer are: * How to develop multi-omics-based high-sensitivity detection methods to accurately capture MRD and monitor postoperative recurrence in lung cancer? * Is adaptive treatment guided by ctDNA-MRD for lung cancer patients superior to traditional clinical management and effectively improves survival? * Do heterogeneous patient populations (grouped by stages, histopathological subtypes, driver mutations, and treatment histories) show differences in effects under ctDNA-MRD guided postoperative management strategies?

Key facts

Study ID

NCT06930807

Run by

Peking University People's Hospital

People needed

1000

Starts

2025-03-25

Expected to finish

2028-07-31

Last updated by the study team

2025-04-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Non-small cell lung cancer with stage IA-IIIA (8th edition TNM classification) planning to undergo curative surgery or to undergo neoadjuvant therapy
• Solid nodules >1 cm or ground-glass nodules >1.5 cm on imaging
• No history of malignancies other than non-small cell lung cancer in the past 5 years
• Specimens are well preserved and imaging documents are accessible.

You may not qualify if…

• Age<18 years old
• Non-small cell lung cancer with pathologic stage IIIB-IV (8th edition TNM classification)
• Pathology results confirmed not to be non-small cell lung cancer
• History of malignancies other than non-small cell lung cancer in the past 5 years

Where it is running

• Peking University People's Hospital — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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