MitoQ and Ischemic Conditioning To Assess Vascular Health Outcomes

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Stroke

In brief

Stroke survivors have compromised vascular function which may contribute to secondary stroke risk, cardiovascular disease, and may limit their exercise tolerance. Preliminary data shows a single bout of ischemic conditioning or oral ingestion of an over-the-counter antioxidant supplement called MitoQ may improve vascular function and muscle activity in individuals post-stroke.

Key facts

Study ID: NCT06930638
Run by: Medical College of Wisconsin
People needed: 30
Starts: 2025-07-22
Expected to finish: 2026-12-31
Last updated by the study team: 2025-09-25

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

18 - 85 years of age
Cortical or sub-cortical stroke ≥ 6 months ago with residual hemiparesis
Able to give informed consent and follow 2-step command.
English Speaking

You may not qualify if…

Unable to stand from chair without physical assistance from another person (able to use assistive device).
History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., wounds in the leg).
Chronic lasting symptoms (> 6 months) of severe COVID-19 (i.e., hospitalization)
History of head trauma or concussion within the past 6 months
Comorbid neurological disorder
Peripheral vascular disease
Myocardial infarction or arrhythmia in the previous year
Resting SBP ≥180 mmHg or DBP ≥ 100 mmHg
Pregnant or breastfeeding.
Other significant medical condition likely to influence study or jeopardize safety as assessed by the Primary Investigator

Where it is running

Medical College of Wisconsin — Milwaukee, Wisconsin, United States (enrolling)

Full record on ClinicalTrials.gov

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