RestoratIon of Myocardial Function by PeRcutaneous cOronary interVEntion in Patients With Ischemic CardioMyoPathy

Recruiting now · Not applicable

Conditions studied: Ischemic Cardiomyopathy

In brief

To compare the effects of physiology- and imaging-guided PCI combined with optimal medical therapy (OMT) versus OMT alone on the recovery of left ventricular systolic function in patients with ischemic cardiomyopathy and multivessel coronary artery disease.

Key facts

Study ID: NCT06930092
Run by: Seoul National University Hospital
People needed: 158
Starts: 2025-08-03
Expected to finish: 2029-04-30
Last updated by the study team: 2026-04-24

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Subject must be ≥ 19 years
Subject is able to verbally confirm understandings of risks, benefits and treatment alternatives of receiving invasive physiologic or imaging evaluation and PCI and he/she or his/her legally authorized representative provides written informed consent prior to any study related procedure.
Subject with LV ejection fraction <40% from cardiac MRI
Subject with multivessel disease in major epicardial coronary artery disease or their major branches (vessel size of 2.5 mm or more than 2.5mm) considering coronary revascularization

You may not qualify if…

Subjects with more than 50% transmural extent of infarction on GE-MRI in more than 25% of the dysfunctional myocardial segments
Subject with suspicious of other cardiomyopathy (dilated cardiomyopathy, hypertrophic cardiomyopathy etc.)
Subject with recent myocardial infarction within 4 weeks
Subject with recent fatal arrhythmia (VT or VF) within 4 weeks
Subject with hemodynamically unstable state
Subject with complex coronary artery lesions, such as chronic total occlusions, in which complete revascularization is considered unfeasible
Subject for whom coronary artery bypass surgery is prioritized over coronary artery intervention
Subject with severe valvular heart disease requiring open heart surgery
Subject with history of coronary artery bypass surgery or valve surgery
Subject with expected life expectancy of less than 1 year
Subject considered ineligible for this study based on the investigator's discretion

Where it is running

Seoul National University Hospital — Seoul, Chongno-gu, South Korea (enrolling)

Full record on ClinicalTrials.gov

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