The Role of Probiotics in the Treatment of Endometriosis (ProMetrioS): a Randomised Double-blinded Placebo-controlled Cross-over Trial

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Endometriosis, Probiotics

In brief

ProMetrioS is a randomised blinded placebo-controlled cross-over trial investigating the effect of specific multistrain probiotics in patients with endometriosis. The aim of this clinical trial is to determine whether probiotic treatment can significantly modulate gut microbiome composition and functionality in endometriosis patients, specifically parameters associated with the estrobolome.

Key facts

Study ID

NCT06929364

Run by

The Gut Microbiome Center (Centar za crijevni mikrobiom)

People needed

40

Starts

2024-11-01

Expected to finish

2025-11-30

Last updated by the study team

2025-04-16

Who can join

Age: any, up to 35. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• adult subjects with stage III or IV endometriosis diagnosis confirmed by biopsy

You may not qualify if…

• Age > 35 years
• Immunocompromised patients
• Patients with chronic inflammatory diseases (e.g., autoimmune disorders)
• Pregnancy
• Use of supplements and foods with probiotics
• Use of immunosuppressant, antibiotic, proton pump inhibitors and corticosteroid drugs
• Use of probiotics product less than one month before start of study or during study

Where it is running

• University Hospital Center Zagreb — Zagreb, Croatia (enrolling)

Full record on ClinicalTrials.gov

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