Heart Rate Variability and Music Listening

Recruiting now · Not applicable

Conditions studied: Heart Rate Variability, Anxiety, Depression

In brief

High anxiety levels may lead to negative outcomes, and previous studies have shown that music listening could reduce periprocedural anxiety and depression. Recent evidence suggests that a lower heart rate variability (HRV) may be associated with anxiety and depression disorders, but the association of these HRV parameters with preoperative mood in the procedural settings are less defined. In this prospective cohort pilot study, the study team will investigate the association between HRV and psychological vulnerability (anxiety, depression) in the presence of music listening before procedures. A total of 120 patients about to undergo procedures (surgery, procedures) will be recruited in three healthcare institutions in Singapore (KK Women's and Children's Hospital, Singapore General Hospital, Changi General Hospital). Patients will be asked to have their ECG readings recorded before, during, and after music listening. Preprocedural information (e.g., demographic, clinical) and psychological scores will be collected.

Key facts

Study ID

NCT06929208

Run by

KK Women's and Children's Hospital

People needed

120

Starts

2025-08-19

Expected to finish

2027-12-01

Last updated by the study team

2026-08-07

Who can join

Age: 21 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• America Society of Anaesthesiologist (ASA) 1 to 3 adults undergoing procedures (surgery, pain procedures);
• Able to read and understand English and/or Chinese;
• Not receiving opioid prior to the procedures.

You may not qualify if…

• With chronic pain;
• Opioid and drug abuse;
• Scheduled postoperative Intensive care unit (ICU) admission;
• With baseline non-sinus heart rhythm or on pacemaker support.

Where it is running

• KK Women's and Children's Hospital — Singapore, Singapore (enrolling)
• Changi General Hospital — Singapore, Singapore
• Singapore General Hospital — Singapore, Singapore

Full record on ClinicalTrials.gov

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