A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)
Running, not enrolling · Phase 2
Conditions studied: Pulmonary Arterial Hypertension
In brief
Researchers are looking for other ways to treat pulmonary arterial hypertension (PAH). Sotatercept is a study medicine that is designed to treat PAH. A past study, MK-7962-024 (LIGHTRAY) (NCT06664801), learned about the safety and effects of sotatercept in people with PAH. One of the goals of that study was to learn about sotatercept when given at a dose (amount) based on the weight range a person is in (weight-banded doses) compared to when given based on a person's exact weight. This is an extension study, which means people who took part in MK-7962-024 (LIGHTRAY) may be able to join this study. In this extension study, people will get weight-banded doses of sotatercept. The main goal of this study is to learn about the safety of weight-banded doses of sotatercept and if people tolerate it over a longer period of time.
Key facts
- Study ID
- NCT06925750
- Run by
- Merck Sharp & Dohme LLC
- People needed
- 130
- Starts
- 2025-05-12
- Expected to finish
- 2028-06-16
- Last updated by the study team
- 2025-12-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- The main inclusion criteria include but are not limited to the following:
- Has completed the treatment period of study MK-7962-024 (LIGHTRAY) (including Visit 11) on study intervention, did not discontinue study intervention, and is able to safely enroll into MK-7962-031 (LIGHTRAY EXTENSION)
- Has not started treatment with commercially available sotatercept
You may not qualify if…
- The main exclusion criteria include but are not limited to the following:
- Has current exposure or is planning to begin treatment with an activin signaling inhibitor (other than sotatercept)
Where it is running
- University of Kansas Medical Center ( Site 1928) — Kansas City, Kansas, United States
- University of New Mexico Health Sciences Center - Department of Internal Medicine ( Site 1916) — Albuquerque, New Mexico, United States
- Centro Medico Capital ( Site 0002) — La Plata, Buenos Aires, Argentina
- Instituto de Investigaciones Clinicas Mar del Plata ( Site 0006) — Mar del Plata, Buenos Aires, Argentina
- Instituto Medico Rio Cuarto ( Site 0010) — Río Cuarto, Córdoba Province, Argentina
- Instituto de Cardiologia Juana F. Cabral ( Site 0008) — Corrientes, Argentina
- Hospital Provincial Jose Maria Cullen ( Site 0005) — Santa Fe, Argentina
- Royal Prince Alfred Hospital ( Site 0103) — Camperdown, New South Wales, Australia
- Westmead Hospital ( Site 0100) — Westmead, New South Wales, Australia
- Wesley Research Institute ( Site 0101) — Auchenflower, Queensland, Australia
- The Alfred Hospital ( Site 0102) — Melbourne, Victoria, Australia
- IUCPQ ( Site 0208) — Québec, Quebec, Canada
- Guangdong Provincial People's Hospital-Cardiology ( Site 2000) — Guangzhou, Guangdong, China
- The Second Xiangya Hospital of Central South University ( Site 2002) — Changsha, Hunan, China
- Shanghai Pulmonary Hospital ( Site 2004) — Shanghai, Shanghai Municipality, China
- Yan an Hospital of Kunming City ( Site 2011) — Kunming, Yunnan, China
- Clinica Colsanitas - Sede Reina Sofia ( Site 0303) — Bogotá, Bogota D.C., Colombia
- Fundacion Santa Fe de Bogota ( Site 0302) — Bogotá, Bogota D.C., Colombia
- IMAT S.A.S ( Site 0301) — Montería, Departamento de Córdoba, Colombia
- Clínica Imbanaco S.A.S ( Site 0304) — Cali, Valle del Cauca Department, Colombia
- Vseobecna fakultni nemocnice v Praze ( Site 0400) — Prague, Praha 2, Czechia
- CHU Bordeaux Haut-Leveque ( Site 0501) — Pessac, Aquitaine, France
- C.H.U Hôpital Nord ( Site 0500) — Marseille, Bouches-du-Rhone, France
- CHU de Rouen ( Site 0503) — Rouen, Haute-Normandie, France
- University of Colorado Anschutz Medical Campus-University of Colorado Hospital Cardiac and Vascular ( Site 1930) — Aurora, Colorado, United States
Full record on ClinicalTrials.gov
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