Using Xe MRI to Guide Radiation Therapy for Lung Cancer
Recruiting now · Phase 2
Conditions studied: Imaging Techniques
In brief
The purpose of this research study is to explore using MRI scans with xenon to better image lung function, how lung function changes after radiation therapy, and to guide radiation therapy away from parts of the lung that have good function. This project is foundational to performing additional studies to establish if novel MRI imaging can serve as a guidance tool for lung cancer radiation treatment.
Key facts
- Study ID
- NCT06925295
- Run by
- Sean Fain
- People needed
- 15
- Starts
- 2025-08-30
- Expected to finish
- 2027-01-01
- Last updated by the study team
- 2026-01-02
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects must meet all of the following inclusion criteria to be eligible for enrollment into the trial
- Aged 18-80 years
- Willing and able to provide informed consent and adhere to visit/protocol schedules (Consent must be given before any study procedures are performed.)
- Clinical diagnosis of lung cancer made by a board-certified oncologist with intent to treat with stereotactic body radiation therapy. We will not exclude individuals based on cancer type or severity of disease with the exception of the below criteria
You may not qualify if…
- Subjects presenting with any of the following will not be included in the trial:
- Subject is less than 18 years old or incarcerated
- MRI is contraindicated based on responses to MRI screening questionnaire
- Subject is pregnant or lactating
- Resting oxygen saturation <90% on supplemental oxygen
- Respiratory illness of bacterial or viral etiology within 30 days of planned treatment
- Subject has history of any known ventricular cardiac arrhythmia
- Subject has history of cardiac arrest within the last year
- Subject has prior history of cancer treatment with radiation therapy to the lung
- Subject has concurrent cancer treatment with agents associated with increased risk of radiation pneumonitis (e.g. immunotherapy, chemotherapy)
- Subject does not fit into 129Xe vest coil used for MRI
- Subject cannot hold his/her breath for 15 seconds
- Subject deemed unlikely to be able to comply with instructions during imaging
- Medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements
Where it is running
- University of Iowa — Iowa City, Iowa, United States (enrolling)
Full record on ClinicalTrials.gov
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