A Dose-Finding Study of Tebapivat to Assess Efficacy, and Safety in Participants With Sickle Cell Disease (SCD)
Running, not enrolling · Phase 2 · Has a placebo group
Conditions studied: Sickle Cell Disease
In brief
The main purpose of this study is to compare the effect of tebapivat versus placebo on anemia and to detect a dose-response for hemoglobin (Hb) response in participants with SCD.
Key facts
- Study ID
- NCT06924970
- Run by
- Agios Pharmaceuticals, Inc.
- People needed
- 59
- Starts
- 2025-05-01
- Expected to finish
- 2027-05-01
- Last updated by the study team
- 2026-05-29
Who can join
Age: 16 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- UCHealth at University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States
- UConn Health — Farmington, Connecticut, United States
- Children's National Hospital — Washington D.C., District of Columbia, United States
- MedStar Washington Hospital Center — Washington D.C., District of Columbia, United States
- Emory-Children's Center/ Children's Healthcare of Atlanta: Arthur M. Blank Hospital — Atlanta, Georgia, United States
- Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
- Boston Medical Center & Boston University School of Medicine — Boston, Massachusetts, United States
- Henry Ford Health System — Detroit, Michigan, United States
- Children's Hospital of Michigan — Detroit, Michigan, United States
- Icahn School of Medicine at Mt. Sinai — New York, New York, United States
- Montefiore Medical Center — The Bronx, New York, United States
- Thomas Jefferson University Hospital — Philadelphia, Pennsylvania, United States
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
- Lifespan at Rhode Island Hospital — Providence, Rhode Island, United States
- Prisma Health Cancer Institute - Farris Road — Greenville, South Carolina, United States
- University of Texas Health Science Center of Houston — Houston, Texas, United States
- Fred Hutchinson Cancer Center, University of Washington — Seattle, Washington, United States
- CHR de la Citadelle — Liège, Wallonne, Belgium
- Clinique CHC MontLégia — Liège, Wallonne, Belgium
- CHU Montreal — Montreal, Quebec, Canada
- Hôpital Edouard Herriot, CHU de Lyon — Lyon, Auvergne-Rhône-Alpes, France
- Institut Universitaire du Cancer de Toulouse - Oncopole — Toulouse, Midi Pyrenees, France
- CHU Hôpital Henri Mondor — Créteil, Île-de-France Region, France
- St. James Hospital — Dublin, Leinster, Ireland
- Amsterdam Universitair Medisch Centrum, Locatie AMC — Amsterdam, North Holland, Netherlands
Full record on ClinicalTrials.gov
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