Team Science (The Liver Health Study)

Completed · Not applicable

Conditions studied: Steatotic Liver Disease of Mixed Origin (MetALD)

In brief

Liver damage from alcohol intake and weight-related behaviors is preventable and treatable only through lifestyle changes. This mixed-methods randomized controlled trial compares standard and enhanced approaches to screening, brief intervention, and referral to treatment/prevention (SBIRT/P) to identify and intervene for metabolism- and alcohol-associated liver disease (MetALD). Our multidisciplinary team aims to show that integrating results of noninvasive liver screening with Fibroscan®, a painless ultrasound that measures stiffness and fat in the liver, can optimize our brief intervention. The study population is adults age 21+ who speak Spanish or English from underresourced communities with alcohol- and weight-related risks for MetALD.

Key facts

Study ID

NCT06924281

Run by

Brown University

People needed

14

Starts

2025-04-25

Expected to finish

2025-08-31

Last updated by the study team

2026-02-04

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Be at least 21 years of age.
• Exceed alcohol intake screening guidelines for MetALD.
• Have a Body Mass Index (BMI) >=25 kg/m2.
• Be able to speak and read English or Spanish to provide written informed consent and understand written and oral instructions in English or Spanish.

You may not qualify if…

• Pre-existing liver disease or hepatocellular carcinoma or prior liver transplant.
• Pre-existing medical conditions that, in the opinion of the investigative team, would interfere with research participation (e.g., loss of kidney function, uncontrolled infections, multiorgan failure, uncontrolled upper gastrointestinal bleeding, other active malignancies except skin cancer).
• Pre-existing mental health conditions that, in the opinion of the investigative team, would interfere with the ability to provide informed consent and understand written and oral instructions (e.g., hepatic encephalopathy, psychotic disorder diagnosis or symptoms).
• Current pregnancy.
• Be anyone who, based on self-reported withdrawal symptoms and the opinion of the investigative team, could not currently safely be withdrawn from alcohol without medical detoxification.
• Currently receiving formalized psychosocial treatment for an alcohol use or drug problem and/or newly taking medications for an alcohol use or drug problem.
• Currently receiving formalized behavioral weight management treatment and/or newly taking weight loss medications.

Where it is running

• Clinica Esperanza Hope Clinic — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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