The Effect of Exercise on Metabolic Alteration

Recruiting now · Not applicable

Conditions studied: Sedentary Behavior, Healthy Participants, Adult

In brief

The goal of this clinical trial is to study the effectiveness of aerobic exercise in treating obesity in adults and to assess the efficacy of exercise. The primary research questions it seeks to address are as follows: * To what extent does exercise increase the total energy expenditure of participants? * Why and how does the energy expenditure from exercise not fully compensate for the total energy expenditure (TEE)? * Researchers will assess the efficacy and potential challenges of using exercise as a treatment for obesity by comparing the measurement data before exercise intervention (week 0), immediately after exercise intervention (week 12), and 8 weeks post-completion of exercise intervention (week 20). Participants will engage in the following activities: * Engage in running sessions supervised five times a week for a duration of 12 weeks. * Attend laboratory sessions both before and after the exercise intervention period for metabolic and anthropometric measurements, as well as sample collection. * Return to the laboratory for further metabolic and anthropometric measurements and sample collection8 weeks post-completion of exercise intervention.

Key facts

Study ID

NCT06923163

Run by

Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences

People needed

80

Starts

2025-05-01

Expected to finish

2027-12-01

Last updated by the study team

2026-01-21

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Sedentary individuals
• BMI ≥ 18.5 kg/m2

You may not qualify if…

• Individuals who have undergone major surgery in the past 6 months (excluding tooth extraction);
• Individuals on long-term medication;
• Individuals with metabolic and cardiovascular diseases such as diabetes, hypoglycemia, and hypertension;
• Individuals with exercise-related injuries, including joint diseases and fractures;
• Individuals diagnosed with infectious diseases such as HIV, tuberculosis, malaria, etc.;
• Individuals with mental and neurological disorders including anorexia nervosa;
• Individuals who have attempted weight loss or gain through various methods in the past three months;
• Individuals in preconception, pregnancy, and lactation periods;
• Individuals with autism and those with metal implants in their bodies.

Where it is running

• Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences — Shenzhen, Guangdong, China (enrolling)

Full record on ClinicalTrials.gov

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