Hemadsorption to Enhance Drug Elimination in Intoxications

Recruiting now · Not applicable

Conditions studied: Intoxication by Drug

In brief

In this trial the investigators assess the effectiveness of applying a hemadsorber (cytosorb®) in removing benzodiazepines or tricyclic antidepressants in intoxicated patients admitted to ICU with prolonged impaired consciousness. This is a one arm interventional investigation where a hemadsorption filter is applied in patients fulfilling inclusion criteria 8 hours after admission. Plasma titer of the neurodepressing drug will be collected sequentially both before and after start of hemadsorption to evaluate the speed of drug elimination before and after application of a hemadsorption filter. Pre- and post filter titers will be obtained to evaluate adsorbability and to evaluate time to saturation of the filter.

Key facts

Study ID

NCT06922786

Run by

Universitair Ziekenhuis Brussel

People needed

18

Starts

2025-05-01

Expected to finish

2029-01-01

Last updated by the study team

2025-05-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• older than18 years
• Admission to ICU
• GCS < 8 or requiring Flumazenil 8 hours after hospital admission
• Having an intoxication with a benzodiazepine or tricyclic antidepressant that we can measure/quantify
• Having a risk factor for delayed drug elimination defined as either Cirrhosis CHILD B/C or chronic kidney insufficiency KDIGO 3b or worse

You may not qualify if…

• Pregnant patient
• Patients in chronic dialysis before admission
• Need for mechanical ventilation for other reasons than intoxications (e.g. pneumonia, neurotrauma)
• Concomitant pathology requiring continued intravenous sedation
• Known history of seizures
• Contra-indication to heparin use
• DNR restricting the use of mechanical ventilation or dialysis

Where it is running

• Universitair Ziekenhuis Brussel — Brussels, Brussels Capital, Belgium (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.