Processed EEG for Monitoring of Anesthetic Depth in Intracranial Tumor Surgery

Recruiting now · Not applicable

Conditions studied: Brain Tumor Adult, Processed EEG, Total Intravenous Anesthesia

In brief

An important feature of neurosurgical anesthesia is early postoperative recovery of consciousness with minimal residual sedation. This is a key factor to enable early neurological assessment and early discovery of postoperative complications. The goal of this single centre clinical trial is to compare propofol/remifentanil anesthesia delivered by manual total intravenous anesthesia (mTIVA) or target controlled infusion (TCI) for intracranial tumor resection via craniotomy. Anesthetic depth will be assessed by a simplified processed EEG (pEEG). The main question is time spent within recommended pEEG- levels from anesthesia induction until end of surgery. Secondary questions are: * mean pEEG-level, time from end of surgery to consiousness, * peroperative propofol/remifentanil consumption * postoperative degree of sleepiness * awareness assessment Participants are adults having have planned surgery for open resection of a brain tumor and will receive general anesthesia with propofol and remifentanil randomized to mTIVA or TCI. pEEG vill be blinded. * Participants will be asked to grade postoperative sleepiness using a specific scale * Follow up regarding awareness will be performed.

Key facts

Study ID

NCT06922500

Run by

Region Skane

People needed

126

Starts

2024-11-21

Expected to finish

2027-07-01

Last updated by the study team

2025-04-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Elective craniotomy for tumor resection
• Adult patient
• Consent to participation

You may not qualify if…

• Cognitive impact affecting infrmed consent
• brain tumor planned for biopsy without resection Tumor localisation not permitting placement of pEEG electrodes.

Where it is running

• Anesthesia and Intensive Care, Skane University Hospital — Lund, Sweden (enrolling)

Full record on ClinicalTrials.gov

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