Tickle Stimulation in Disorders of Consciousness (DoC)

Recruiting now

Conditions studied: Disorders of Consciousness

In brief

The aim of this project is to investigate whether tickling stimulations can have a short-term effect on the responsiveness of patients with Disorders of Consciousness due to Severe Acquired Brain Injury and to compare this effect with that of neutral tactile stimulations that do not induce tickling.

Key facts

Study ID

NCT06922162

Run by

Anna Estraneo

People needed

45

Starts

2023-06-30

Expected to finish

2025-10-31

Last updated by the study team

2025-04-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of disorders of consciousness (DoC) based on the CRS-R scale;
• Age ≥18 years;
• Time since the event ≥ 28 days

You may not qualify if…

• Large craniectomy that may interfere with fNIRS recording; Unstable clinical conditions (e.g., respiratory failure, fever, status epilepticus, etc.);
• Fractures, paralysis, injuries, or muscular dystrophy that prevent proper stimulation of the aforementioned body parts;
• Lack of informed consent from the legal representative.

Where it is running

• Fondazione Don Gnocchi — Sant'Angelo dei Lombardi, Avellino, Italy (enrolling)
• Coma Science Group - University of Liege — Liège, Belgium, Belgium

Full record on ClinicalTrials.gov

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