Ultrasound-guided Cryobiopsy of Mediastinal/Hilar Lymph Nodes
Recruiting now · Not applicable
Conditions studied: Lung Cancer (NSCLC)
In brief
EBUS-guided cryobiopsy of mediastinal and hilar lymph nodes has shown to be a useful diagnostic tool to obtain tissue for histological analysis and further targeted therapies in lung malignancies. Due to the large size and better quality of the tissue samples, a higher diagnostic yield than with transbronchial needle aspiration (TBNA) can be expected, especially in non-solid tumors. In previous studies different biopsy protocols were used. The freezing time of cryoprobe (which defines the sample sizes) ranged from 3 to 7 s and the number of biopsies was between 1 and 4 samples. It is therefore unclear what freezing times and biopsy frequency are required to obtain the best histological information.
Key facts
- Study ID
- NCT06921681
- Run by
- University of Zurich
- People needed
- 136
- Starts
- 2025-03-07
- Expected to finish
- 2029-12-31
- Last updated by the study team
- 2025-04-10
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- At least one mediastinal lesion or hilar 1 cm or longer in the short axis requiring diagnostic bronchoscopy
- Age between 18 and 90 years
- Written informed consent after participant's information
You may not qualify if…
- Age < 18 and > 90 years
- Lacking ability to form an informed consent (including impaired judgement, communication barriers)
- Contraindication against bronchoscopy (e.g. co-morbidities)
- Mediastinal abscess or cyst
- Extraordinary blood supply of the lesion visualized by EBUS bronchoscope
- INR > 1.5 or Thrombocytes < 100 G/l
- Clopidogrel or other new antiplatelet drugs within 7 days before biopsy (salicylic acid alone allowed)
- Anticoagulation with NOAC within 48 hours before biopsy
- Pulmonary lesions suspicious of lung carcinoma
Where it is running
- Jürgen Hetzel — Basel, Switzerland (enrolling)
Full record on ClinicalTrials.gov
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