STI Testing to Enhance PrEP Use in Pregnancy

Recruiting now · Phase 3

Conditions studied: PrEP Adherence, Sexually Transmitted Infections (STIs), Pregnancy

In brief

The investigators are conducting a study in Botswana to see if offering STI testing along with expanded HIV prevention options (PrEP) helps more pregnant women start and continue using PrEP during and after pregnancy. Pregnant women (n=600) seeking antenatal care in Botswana will be enrolled and randomly assigned to receive the standard of care (standard STI assessment with no STI testing) versus STI testing for Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis during pregnancy and postpartum. The investigators' hypothesis is that providing STI testing alongside PrEP offer will encourage more women to start and continue using PrEP.

Key facts

Study ID: NCT06919614
Run by: Botswana Harvard AIDS Institute Partnership
People needed: 600
Starts: 2025-06-18
Expected to finish: 2029-08-31
Last updated by the study team: 2026-06-11

Who can join

Age: any. Sex: female. Healthy volunteers: accepted.

You may qualify if…

Pregnant and seeking antenatal care
Self-identifying as a cis-gender woman
Living without HIV
Not currently using PrEP
Planning to remain in the city/town of enrolment until 9 months post-delivery.
Planning to receive antenatal and postnatal care in the city/town of enrolment.
Willing and able to provide informed consent

You may not qualify if…

Male gender
Not pregnant
Living with HIV
Currently using PrEP
Not planning to remain in the city/town of enrolment until 9 months post-delivery
Not planning to receive antenatal and postnatal care in the city/town to enrolment
Not able or willing to provide informed consent for participation

Where it is running

DHMT Clinics — Gaborone, Botswana (enrolling)

Full record on ClinicalTrials.gov

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