The Investigators Are Comparing Lidocaine and Papaverine Nerve Blocks to Determine Which Improves Blood Flow Better, Making the "Phoenix Sign" Clearer on Imaging. This Helps Accurately Diagnose Nerve Compression, Improving Patient Care
Completed · Not applicable
Conditions studied: Drop Foot
In brief
This pilot study aims to investigate the effects of nerve blocks in patients with diabetic peripheral neuropathy through a double-blinded, randomized trial involving 4 patients. Each participant will receive bilateral peripheral nerve blocks using either lidocaine or papaverine. Following randomization, each patient will receive one medication in one leg and the alternate medication in the contralateral leg. Researchers will measure parameters including motor strength, sensory function (two-point discrimination), arterial blood flow via Doppler ultrasound, and microvascular perfusion using near-infrared spectroscopy both prior to and following nerve block administration. This research seeks to explore potential diagnostic and therapeutic applications for peripheral nerve entrapment, a common yet challenging clinical condition.
Key facts
- Study ID
- NCT06919289
- Run by
- US Neuropathy Centers
- People needed
- 4
- Starts
- 2024-03-07
- Expected to finish
- 2024-07-01
- Last updated by the study team
- 2025-04-09
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- subjects were included if they were diabetic and neuropathic.
You may not qualify if…
- Patients with Trypanophobia
Where it is running
- Indiana Foot and Ankle — Jasper, Indiana, United States
Full record on ClinicalTrials.gov
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