BID LTM Digital Intervention in Aging

Recruiting now · Not applicable

Conditions studied: Long-Term Memory, Inhibitory Control, Mild Cognitive Impairment

In brief

Healthy aging is typically accompanied by diminished capability for learning and retrieval of high-fidelity long-term memory (LTM). The decline in these faculties is accelerated and becomes significant deficits in LTM and cognitive control functions at the level or a diagnosis of Mild Cognitive Impairment (MCI). Training with the navigation game, relative to training with control games, is expected to improve LTM performance for older adult participants. Researchers will compare two different digital interventions to assess whether they may be helpful in improving cognitive function. Participants will conduct study activities remotely (e.g., at-home): 1. Baseline Assessment. Complete a series of cognitive assessments and surveys. 2. Intervention. Engage in a digital intervention for up to 8 weeks. 3. Post Intervention Assessment. Complete the same cognitive assessments and surveys as the Baseline Assessment. 4. Follow-Up Assessment. Six months after the intervention ends, participants will complete the same cognitive assessments and surveys as the Baseline Assessment.

Key facts

Study ID

NCT06916221

Run by

University of California, San Francisco

People needed

150

Starts

2025-08-20

Expected to finish

2028-07-31

Last updated by the study team

2026-04-02

Who can join

Age: 60 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Minimum of 12 years of education
• English fluency: All task instructions are presented in English language text. In order to control for sufficient and equivalent participant comprehension of the procedures and instructions, we require their self-report of fluency in English.
• Normal or corrected-to-normal vision
• Normal or corrected-to-normal hearing
• Medically healthy older adults, including those with below-average cognitive performance /MCI patients without dementia referred by neuropsychologists (i.e., no participant medical records will be reviewed).

You may not qualify if…

• Under the age of 60
• Clinical diagnosis of neurological or psychiatric disorder Clinical diagnosis of dementia or AD8 score of >4
• Visually or hearing impaired without correction to normal
• Regularly (one or more times per week) practicing an instrument within the last year
• 10 years or more of formal musical instrument training

Where it is running

• University of California, San Francsico — San Francisco, California, United States (enrolling)

Full record on ClinicalTrials.gov

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