PEACE Trial: Postpartum Evaluation of Antihypertensive Cessation and Efficacy
Recruiting now · Phase 4
Conditions studied: Postpartum Hypertension (PPHT)
In brief
This randomized controlled trial compares two common medications, labetalol and extended-release nifedipine, to determine which is more effective at managing postpartum high blood pressure. We hypothesize that extended-release nifedipine will better control blood pressure and reduce the need for continued medication beyond six weeks postpartum. The study will enroll 110 postpartum participants, randomly assigning them to one of the two medications, with remote blood pressure monitoring to evaluate treatment effectiveness and inform postpartum hypertension management.
Key facts
- Study ID
- NCT06915792
- Run by
- University of California, Los Angeles
- People needed
- 110
- Starts
- 2025-06-01
- Expected to finish
- 2027-10-31
- Last updated by the study team
- 2026-06-05
Who can join
Age: 18 and older, up to 64. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years Delivery at study institution at ≥28 weeks gestation Postpartum SBP > 150 and/or DBP > 100 OR 2 or more SBP > 140 and/or DBP > 90 within a 24-hour period Require initiation of an oral antihypertensive medication during postpartum hospital stay or within 7 days of discharge Treating obstetric team amenable to starting either study medication
You may not qualify if…
- Treated with oral antihypertensive medications prior to delivery Known allergies or contraindications to nifedipine or labetalol History of moderate persistent to severe asthma, chronic obstructive pulmonary disease, heart failure, or greater than first-degree atrioventricular heart block Unable to provide written informed consent in English
Where it is running
- UCLA Ronald Reagan — Los Angeles, California, United States (enrolling)
Full record on ClinicalTrials.gov
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