Modulation of the Inflammatory Response in Bariatric Surgery

Recruiting now

Conditions studied: Obesity, Bariatric Surgery Candidate, Inflammation, Postoperative Pain, Opioid-Free Anesthesia, Heart Rate Variability

In brief

This study will evaluate how different anesthesia techniques affect inflammation after bariatric surgery. Patients will be randomly assigned to receive one of three approaches: opioid-free anesthesia, intravenous anesthesia with opioids, or inhalational anesthesia with opioids. The study will measure blood levels of inflammation-related substances (such as IL-6, CRP, cortisol, ESR , WBC and lactate) at several time points before and after surgery. Heart rate variability will also be monitored as an indicator of the body's stress response. The results may help identify anesthesia strategies that reduce inflammation and improve recovery in patients undergoing bariatric surgery.

Key facts

Study ID

NCT06915558

Run by

Hospital HM Nou Delfos

People needed

90

Starts

2024-12-02

Expected to finish

2025-12-02

Last updated by the study team

2025-04-08

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients scheduled for bariatric surgery.
• Age 18-65 years.
• BMI ≥ 30 kg/m².
• ASA physical status II-III.

You may not qualify if…

• Pregnancy or breastfeeding.
• Chronic opioid use before surgery.
• Severe renal or hepatic failure.
• Uncontrolled psychiatric disorders.
• Significant intraoperative complications requiring protocol deviation.

Where it is running

• Hospital HM Nou Delfos — Barcelona, Barcelona, Spain (enrolling)

Full record on ClinicalTrials.gov

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