Immunotherapy: Care and Prevention of Infectious and Tumoral Diseases (ImmunoHUB)
Recruiting now
Conditions studied: SARS CoV-2, Liver Tumours
In brief
The project comprises two research lines. In the line 1, human monoclonal antibodies toward SARS-CoV-2 will be generate and characterized by in vitro functional tests. In the line 2, in vitro tests will be performed to evaluate the efficency of immune response mediated by antibodies direct to specific tumor molecules.
Key facts
- Study ID
- NCT06914635
- Run by
- Fondazione IRCCS Policlinico San Matteo di Pavia
- People needed
- 40
- Starts
- 2023-05-30
- Expected to finish
- 2027-02-01
- Last updated by the study team
- 2025-04-06
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Line 1: - Age >18 at time of signing informed consent form
- Signed informed consent form Line 2: - Primery liver tumor
- Age >18 at time of signing informed consent form
- Signed informed consent form
You may not qualify if…
- Line 1: - Active or history of neoplastic malignancy
- Active autoimmune disease ongoing treatment with immunosuppressive therapy
- Evidence of positive HIV, HCV, HBV test
- Diabetes
- Failure to sign informed consent form Line 2: - Concomitant diseases with life expectancy of less than 12 months
- Chronic autoimmune or inflammatory diseases
- Treatment with atezolizumab, bevacizumab, sorafenib, lenvatinib, regorafenib, cabozantinib, checkpoint inhibitors and tyrosine kinase inhibitors or anti-VEGF therapies
- Other extrahepatic neoplasms occurring or in the last 3 years except for tumors resected with curative intent and without evidence of relapse for >3 years prior to signing informed consent and considered low risk of relapse
- HIV infection
- Failure to sign informed consent form
Where it is running
- Fondazione IRCCS Policlinico San Matteo di Pavia — Pavia, Pavia, Italy (enrolling)
Full record on ClinicalTrials.gov
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