Long-Term Multidisciplinary Physiotherapy for Breast Cancer Survivors: A Randomized Controlled Trial

Recruiting now · Not applicable

Conditions studied: Breast Cancer, Breast Cancer Female

In brief

This multi-center randomized controlled trial (RCT) evaluates the long-term (12-month) effectiveness of a standardized multidisciplinary physiotherapy program versus standard care on persistent pain, upper limb (UL) dysfunction, and cancer-related fatigue (CRF) in breast cancer survivors. The study also examines improvements in quality of life and psychological well-being. The standardized intervention combines specific exercise therapy, manual therapy, education, and mind-body interventions and is designed to produce sustained benefits beyond the acute rehabilitation phase.

Key facts

Study ID

NCT06913244

Run by

Al Hayah University In Cairo

People needed

146

Starts

2025-04-23

Expected to finish

2027-01-01

Last updated by the study team

2025-04-06

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Women aged between 18 and 65 years. History of breast cancer surgery (with or without axillary lymph node dissection).
• Completed acute cancer treatment (surgery, chemotherapy, and/or radiation) at least 6 months prior to enrollment.
• Currently in the survivorship phase, with no active evidence of disease.
• Experiencing persistent sequelae related to treatment, such as:
• Moderate to severe pain (e.g., VAS score ≥ 30 on a 0-100 scale), and/or Upper limb dysfunction, and/or Cancer-related fatigue (as measured by FACIT-Fatigue). Able to understand and provide written informed consent.

You may not qualify if…

• Diagnosis of recurrent or metastatic breast cancer. Currently receiving active cancer treatment (chemotherapy, radiation for active disease, or immunotherapy).
• Participation in another interventional trial targeting pain or rehabilitation within the past 3 months.
• Presence of severe comorbidities (e.g., uncontrolled cardiovascular disease, severe orthopedic or neurological conditions) that would preclude safe participation in physiotherapy.
• Any physical or psychological condition that, in the opinion of the investigator, would interfere with participation or adherence to the study protocol (e.g., severe cognitive impairment).
• Pregnancy or breastfeeding.

Where it is running

• Faculty of Physical Therapy, Al Hayah University — Cairo, Egypt (enrolling)

Full record on ClinicalTrials.gov

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