FET in Adenomyosis
Starting soon · Not applicable
Conditions studied: Adenomyosis
In brief
Purpose of the Study: To compare the effectiveness of GnRH agonist downregulation alone versus GnRH agonist combined with letrozole in improving pregnancy outcomes in women with adenomyosis undergoing frozen embryo transfer (FET). Research Question: Is the combined use of GnRH agonist and letrozole more effective than GnRH agonist downregulation alone in achieving better ongoing pregnancy rates in adenomyosis cases undergoing FET? Hypothesis: Null Hypothesis (H₀): The combined use of GnRH agonist and letrozole is not more effective than GnRH agonist downregulation alone in achieving a higher ongoing pregnancy rate in adenomyosis cases undergoing FET. Study Outcomes: Primary Outcome: Ongoing pregnancy rate at 12 weeks of gestation.
Key facts
- Study ID
- NCT06913075
- Run by
- Indira IVF Hospital Pvt Ltd
- People needed
- 700
- Starts
- 2026-06-25
- Expected to finish
- 2026-12-23
- Last updated by the study team
- 2026-01-26
Who can join
Age: 21 and older, up to 42. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of adenomyosis confirmed via transvaginal ultrasound as per MUSA criteria History of infertility requiring frozen embryo transfer (FET). Availability of at least one good-quality frozen embryo for transfer
You may not qualify if…
- BMI ≥ 30 kg/m2 Presence of endocrine disorders; (uncontrolled diabetes mellitus, / hyperprolactinemia, thyroid dysfunction, Congenital adrenal hyperplasia, Cushing syndrome, or polycystic ovary syndrome Previous major uterine surgery Gestational carrier Fertility preservation
Where it is running
- Indira IVF Pvt Hospital — Udaipur, Rajasthan, India
Full record on ClinicalTrials.gov
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